Skye Bioscience Rockets 41% on Promising Preclinical Weight Loss Data
Skye Bioscience, Inc. (NASDAQ: SKYE) soared over 40% to lead the PRISM Emerging Weight Loss Index after announcing compelling new preclinical results from a murine diet-induced obesity model. The company’s novel CB1-targeting antibody, nimacimab, delivered a greater than 30% reduction in body weight when combined with the GLP-1/GIP agonist tirzepatide. Nimacimab alone produced 23.5% weight loss, comparable to either tirzepatide or the older small molecule monlunabant, highlighting the antibody’s standalone potential.
Skye’s data also suggests nimacimab’s unique allosteric mechanism of action avoids competitive interference at the CB1 receptor—preserving potency even under high-ligand conditions typical in obesity. With Phase 2a data expected later this year, the company is positioning nimacimab as a differentiated option in combination or monotherapy for metabolic disorders. CEO Punit Dhillon noted, “We believe nimacimab may offer the widest possible therapeutic window among CB1 inhibitors,” setting the stage for a potential shift in the weight loss treatment landscape.
Applied Digital Plunges 32% as Market Digests Datacenter Strategy Shift
Shares of Applied Digital Corporation (NASDAQ: APLD) fell over 30%, dragging the PRISM Emerging AI Datacenter & Infrastructure Index lower following its fiscal Q3 2025 results. While quarterly revenue climbed 22% year-over-year to $52.9M, the company posted a GAAP net loss of $36.1M and an adjusted net loss of $17.8M.
The sell-off was likely exacerbated by the company’s decision to divest its Cloud Services Business, a unit that had driven substantial revenue gains. Management cited a strategic focus on its data center hosting platform as part of a potential transition toward a REIT structure. The company also disclosed construction remains on schedule for its 369,000+ sq. ft., 100 MW Ellendale data center, with active discussions underway to lease 400 MW across the campus.
Other PRISM Mid-Day Movers:
- Knightscope, Inc. (KSPC) up 38.17%
- Biostem Technologies Inc. (BSEM) down 17.07%
- BullFrog AI Holdings, Inc. (BDRX) down 13.94%
- CISO Global Inc. (CISO) up 12.29%
The post PRISM Mid-Day Movers: Surging Weight Loss Innovation and Datacenter Headwinds appeared first on PRISM MarketView.